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20160216 Sartorius Stedim – Membrane Chromatography in Biopharmaceutical

Last updated 623 days ago by Albert Verver

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Group of Users of Technology for Separation in the Netherlands


 

20160216 Sartorius Stedim GmbH – Mr. Stefan Fischer-Frühholz – Membrane Chromatography in Biopharmaceutical manufacturing

Sartorius produces and commercialises Sartobind symmetric microporous (3-5 µm) membrane adsorbers with functionalised groups that act as chromatographic resins, but with much shorter diffusion path lengths, higher porosity, larger internal adsorption area, and lower pressure drops than the resin beads. The capacity is about 2 kg protein/kg Sartobind. The shorter path lengths lift the diffusion limitation.

The binding capacity becomes much less dependent on molecular weight and independent from flow rate till high throughputs with sharper breakthrough curves in much  smaller bed volumes. smaller total plant size and system volume, which also saves CIP costs. Applications are in mAb  production and purification of viruses. www.sartorius-stedim.com

 

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