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20160913 NL GUTS Presentations Affinity Separation

Last updated 662 days ago by Albert Verver


NL GUTS Group of Users of Technology for Separation in the Netherlands





Copies of the presentations can be downloaded from the NL GUTS member site
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20160913 VITO (BE) – Mr. Roel Vleeschouwers – “Membrane extraction: innovative combination of affinity separation with functionalised membranes”

With its sustainable chemistry program, the Belgian institute VITO develops integrated separation and conversion technologies on basis of membrane contactors. One application is membrane extraction, where the membrane separates the liquid phases and allows the solute to pass. VITO used commercially available fibres to demonstrate that volatile fatty acids can be recovered by membrane based reactive extraction from a mixed culture fermenter as part of bio-refining optimising extraction conditions. Changing the solvent for en enzymatic reaction allows higher reactant concentrations and 99% conversion through removing de product MPPA with membrane extraction. VITO applied Grignard Grafting on ceramic membranes pore walls to attach functional groups on the pore wall that act as a chromatographic adsorbent. This FunMem process enables continuous separation of donor amines and chiral products with increased selectivity. www.vito.be 


20160913 BODEC – Mr. René Houben - “Early Adopter Project Results: Direct adsorption from complex streams with Cadans”

With the Cadans pilot installation available from a former ISPT project Bodec together with NL GUTS members Avebe and Cosun verified if the perceived advantages of the Two Moving Bed (TMB) as alternative for a packed bed are real. In a TMB the resin is in constant movement, operated in three reactors in counter current setting. Hydrocyclones separate the resins from the liquid. Avebe focuses on removing glycol-alkaloids and Cosun on recovering proteins. Several resins (adsorption isotherms) and process conditions were tested. Both adsorption and desorption work. Desorption efficiency as with packed bed. Short contact time is feasible. Pilot unit shows process limitations to be solved prior to physical modification to establish scale-up. Cadans is promising. www.bodec.nl


20160913 Biogonaal – Mr. John Krijgsman – “Affinity separation DSP”

The basics of downstream processing should not be forgotten and that is what the new edition of ‘Biotechnology, Downstream’ by Wesselingh and Krijgsman is all about. Affinity separation as part of the purification of bio-products is highlighted by elucidating how the properties of the adsorbents (nanofibers, gels, beads: material, ionic charge, size and shape and affinity forces) and of the (protein) molecules to be recovered determine separation performance. From simple experiments to determine adsorption isotherms to non-linear adsorption and elution profiles in columns and scale-up rules to full size axial and radial packed, expanded and simulated moving bed columns. biogonaal@gmail.com


20160913 Pectcof B.V. - Mrs. Femke Vertregt; Mr. Rudi Dieleman - “Unlocking the potential of coffee pulp biomass”

Coffee pulp, all coffee berry material around the coffee bean, constitutes 20 million ton of biomass/year, that is all waste dumped. It has little fertiliser value, but contains 12% pectins and 8% proteins. Pectcof targets these compounds with an extraction process to produce materials for food ingredients, bio-chemicals and bio-fuel. The extraction features hydrolysis followed by an enzymatic coupling reaction to Dutchgum, an Arabic gum-like compound with emulsifying properties, for applications in paints, facial creams, soft drinks and dairy products. The extraction is carried out in the coffee growing countries while the processing is done in The Netherlands. The process has been developed with a large number of industry and science partners. www.pectcof.com 


20160913 Neutralox GmbH (DE) – Mr. Udo Laser – “Neutralox”

Neutralox in Germany (represented in NL by Merrem & LaPorte) combines generating oxidative Oxygen radicals in air by UV light with the catalytic properties of an adsorbent to destroy organic compounds in gas streams. Originally the process was developed to remove smell from wastewater off gases. Today Neutralox is also applied for destruction of hazardous and smelly constituents in industrial off gases from dryers, truck-loading, vent gases etc. The catalytic adsorber is the essential element to enable handling large variations of organic load in the feed stream. It adsorbs the overload in its matrix for gradual destruction later when the load is reduced. This also results in compact units with small footprints and low pressure drops or power consumption. The process can be switched off and on at will and requires hardly any start-up period in the temperatures from -30 to +50°C. www.neutralox.de; www.merrem.nl


20160913 LentiKat’s a.s. (CZ) – Mr.Alex Schmeetz – “LentiKat’s Biotechnologies: easy separation of biocatalysts by immobilisation”

LentiKat’s, a SME from Czech Republic, commercialises proprietary technology of biocatalysts in form of enzymes, proteins, bacteria, yeasts, spores or fungi immobilised in a matrix of porous PVA in the shape of 0,2-0,3 mm thick lentils of 3-4 mm diameter. The lentils are suspended in the liquid in which the agents move to the lentils, diffuse in the pores, adsorb on the catalyst and the products desorb and leave the lentils again. With a high biocatalyst density reaction times are short (120→10 min) reactors are compact, reducing cost. Biomass is used repetitively and separation of compounds is simplified leading to lower operating cost. Permeability up to 7.600 Da for sugars and 14.200 Da for proteins. Commercial applications are in pharma and food, biofuels and biochemical, waste- and well water. Examples are conversion of BA to BPA, production of sialic acid, hydrolysis of sucrose, starch and molasses for biofuel, (de)nitrification, chiral amines. R&D topics are mini-packed bed and continuous flow reactors, partly in EU supported project. www.lentikats.eu


20160913 Avans Applied University Breda- Mr. David Mendez Sevillano - ”Group contribution as a tool for solvent selection in the case of DSP of antioxidants”

The work, originally at TU Delft in an ISPT project, is part of the valorisation of okara, the waste from producing soybean milk. Usually these 0,1% dw Isoflavones are extracted in ethanol/water, which is slow. By breaking down the functional groups from the polyphenol structure and building them up again later, models were developed and validated to predict the solubility of polyphenols in different solvents and to predict the related affinities. This enables selecting the optimum solvent and solvent mixtures. www.avans.nl; www.coebbe.nl 


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For more information about NL GUTS please contact:
Jan Koning (chairman NL GUTS)
tel +32 473 976 135 - koning@trionpartners.nl
Bart Manders  (contact at RVO)
tel +31(0)88 602 2329 - bart.manders@rvo.nl


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